Basic Information
VIS ID
TVIS44010943
Fusion event
HTLV-1-DLEU1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr13
Cytoband
q14.3
Reference genome
GRCh37/hg19
Start
50947226/50373090 (Hg38)
End
50947226/50373090 (Hg38)
Orient
-
Location type
ncRNA_intronic
Target gene
DLEU1
miRNAs that regulate target gene
hsa-mir-640 ; hsa-mir-4264 ; hsa-mir-4797-3p ; hsa-mir-5699-3p ; hsa-mir-4421 ; hsa-mir-622 ; hsa-mir-3934-5p ; hsa-mir-764 ; hsa-mir-125a-3p ; hsa-mir-378a-5p ; hsa-mir-6821-3p ; hsa-mir-6790-3p ; hsa-mir-3653-5p ; hsa-mir-372-5p ; hsa-mir-371a-5p ; hsa-mir-616-5p ; hsa-mir-373-5p ; hsa-mir-371b-5p ; hsa-mir-4713-5p ; hsa-mir-506-3p ; hsa-mir-124-3p ; hsa-mir-2116-3p ; hsa-mir-4736 ; hsa-mir-532-3p ; hsa-mir-150-5p ; hsa-mir-488-5p ; hsa-mir-940 ; hsa-mir-6893-5p ; hsa-mir-6808-5p ; hsa-mir-3910 ; hsa-mir-3714
Nearest miRNA
hsa-mir-15a/Upstream/323889; hsa-mir-1267/Downstream/975477;
Nearest TSS
ENST00000623511/Upstream/247370; ENST00000413510/Downstream/154359;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/239207, chr13-CpG: 62/Downstream/470145
Nearest cancer related gene
DLEU1(TSG, No orient, 0)
Upstream sequence
ggataagtgaccaggtatagtacaatcacttctgggtcaaatggtaattgcgtgcttagttttgtaataaattgccaaactgtttttcagagtggctata
Downstream sequence
tcattttacatATTACttatatatgtatatataaattttttaaataataaaaattttattatatagttttaaaaaaCATGACATCAGATAATTTTGTTTT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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