Basic Information
VIS ID
TVIS44011004
Fusion event
HTLV-1-ACTN1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr14
Cytoband
q24.1
Reference genome
GRCh37/hg19
Start
69378928/68912211 (Hg38)
End
69378928/68912211 (Hg38)
Orient
-
Location type
Exonic
Fragile sites / regions
FRA14C
Target gene
ACTN1
miRNAs that regulate target gene
hsa-mir-218-5p ; hsa-mir-193b-3p ; hsa-mir-1-3p ; hsa-mir-93-3p ; hsa-mir-615-3p ; hsa-mir-16-5p
Nearest miRNA
hsa-mir-208a/Upstream/1470281; hsa-mir-1185-1/Downstream/3604609;
Nearest TSS
ENST00000550708/Upstream/22069; ENST00000553944/Downstream/8827;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/37108, chr14-CpG: 176/Downstream/65711
Upstream sequence
GAGACGAGATGGTGATGGCGGGATGGAACAAAGCAGAAACCCACCTTCCACGGAGATGTCCTGGATGGCAAAGCGCAGGATGATGGTCCAGATCATGCCC
Downstream sequence
AGGGTCATCTTCACATTCCCATCCACGATTTCTACAGAAACAGCAGCAGCACACATCAGAAAGGGCCTCAGCGGGGACAGAATTAACACTCCCTCAGCAC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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