Basic Information
VIS ID
TVIS44011010
Fusion event
HTLV-1-CEP128 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr14
Cytoband
q31.1
Reference genome
GRCh37/hg19
Start
81221295/80754951 (Hg38)
End
81221295/80754951 (Hg38)
Orient
-
Location type
Intronic
Target gene
CEP128
miRNAs that regulate target gene
hsa-mir-193b-3p ; hsa-mir-375 ; hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-10a-5p ; hsa-mir-6755-3p ; hsa-mir-367-5p ; hsa-mir-1267 ; hsa-mir-4762-5p ; hsa-mir-548t-3p ; hsa-mir-548ap-3p ; hsa-mir-548aa
Nearest miRNA
hsa-mir-1260a/Upstream/3488661; hsa-mir-1185-1/Downstream/13193275;
Nearest TSS
ENST00000550708/Upstream/174526; ENST00000557096/Downstream/6641;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/892963, chr14-CpG: 29/Downstream/186415
Upstream sequence
GCCTTACCATACCTTGTTAGAACTTGTTACAAAAACATACCCCTCATCTACGGAAACTGCTTACCTGGCATTCCTTAATGACCAtgtgatggttaacact
Downstream sequence
gagtgccaaactgattagactgaaggatacaaagtattgagcctgggtgtgtctgtgagggtgtttccaaaggagattaacatttgagtcagtgggctgg
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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