Basic Information
VIS ID
TVIS44011026
Fusion event
HTLV-1-TLN2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr15
Cytoband
q22.2
Reference genome
GRCh37/hg19
Start
62789145/62496946 (Hg38)
End
62789145/62496946 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA15A
Target gene
TLN2
miRNAs that regulate target gene
hsa-mir-194-5p ; hsa-mir-132-3p ; hsa-mir-4314 ; hsa-mir-6508-3p ; hsa-mir-4726-5p ; hsa-mir-4640-5p ; hsa-mir-378g ; hsa-mir-4486 ; hsa-mir-6860 ; hsa-mir-612 ; hsa-mir-5189-5p ; hsa-mir-3187-5p ; hsa-mir-1285-3p ; hsa-mir-4328 ; hsa-mir-25-5p ; hsa-mir-658 ; hsa-mir-6087 ; hsa-mir-6804-5p ; hsa-mir-6856-5p ; hsa-mir-6758-5p
Nearest miRNA
hsa-mir-10393/Upstream/153808; hsa-mir-11181/Downstream/327011;
Nearest TSS
ENST00000557528/Upstream/43354; ENST00000474847/Downstream/64419;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/104749, chr15-CpG: 21/Downstream/200769
Nearby gene
MGC15885(-140226) ;
Upstream sequence
ATTTAAATATACTTAATTTGTAAAATGAGCTGTGTTCTGTAGGCAGATAGGAGTATTTGTGTTCTGCCTTTATTGCATGTACACAGGCAGAGCACAGGCC
Downstream sequence
TCTGCTCCTGGTGATGGTAAGTAGTCTCCAGTCGTGCCTCCCTCCCCTCAGATGGAGGTAATTTCTTCCTCCTCTGGATTATACCTGTCCCTTACATGTG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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