Basic Information
VIS ID
TVIS44011030
Fusion event
HTLV-1-TIPIN integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr15
Cytoband
q22.31
Reference genome
GRCh37/hg19
Start
66638628/66346290 (Hg38)
End
66638628/66346290 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA15A
Target gene
TIPIN
miRNAs that regulate target gene
hsa-mir-484 ; hsa-mir-1273e ; hsa-mir-6516-5p ; hsa-mir-455-3p ; hsa-mir-6807-5p ; hsa-mir-506-3p ; hsa-mir-124-3p ; hsa-mir-650 ; hsa-mir-3612 ; hsa-mir-6499-3p ; hsa-mir-4722-5p ; hsa-mir-2467-3p ; hsa-mir-6086 ; hsa-mir-377-5p ; hsa-mir-1827 ; hsa-mir-1233-3p ; hsa-mir-1225-3p ; hsa-mir-219b-3p ; hsa-mir-6840-3p ; hsa-mir-665 ; hsa-mir-4459 ; hsa-mir-4768-3p ; hsa-mir-4257 ; hsa-mir-940 ; hsa-mir-6893-5p ; hsa-mir-6808-5p ; hsa-mir-6511a-5p ; hsa-mir-1910-3p ; hsa-mir-4695-5p ; hsa-mir-302f ; hsa-mir-3910 ; hsa-mir-3714 ; hsa-mir-548s ; hsa-mir-7703 ; hsa-mir-6720-5p ; hsa-mir-6512-3p ; hsa-mir-1227-3p ; hsa-mir-3926 ; hsa-mir-4252 ; hsa-mir-6889-3p ; hsa-mir-3190-5p ; hsa-mir-4793-3p ; hsa-mir-766-3p ; hsa-mir-6849-3p ; hsa-mir-1273g-3p ; hsa-mir-508-5p ; hsa-mir-3975 ; hsa-mir-6746-5p ; hsa-mir-6771-5p ; hsa-mir-20b-3p ; hsa-mir-2114-5p ; hsa-mir-5588-3p ; hsa-mir-7977 ; hsa-mir-891a-3p
Nearest miRNA
hsa-mir-10393/Upstream/305958; hsa-mir-11181/Downstream/150668;
Nearest TSS
ENST00000557528/Upstream/14587; ENST00000425818/Downstream/10395;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/52134, chr15-CpG: 36/Downstream/10156
Upstream sequence
gcccgtcttggcctcccaaagtgctaggattacaagcgtgagccactgcgcctggccttaatttatctttttttttttttttttttaCTGCCATAGAATA
Downstream sequence
TAGAGCCTGAAATCCAAGTTAATTTACACCTCTGCATAGATGGCTCCCCCATTCAAAATCACCTCTGCCTGACCTCTACTGTTCATTCAAAATACTTTTT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate