Basic Information
VIS ID
TVIS44011034
Fusion event
HTLV-1-UBE2Q2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr15
Cytoband
q24.2
Reference genome
GRCh37/hg19
Start
76183754/75891413 (Hg38)
End
76183754/75891413 (Hg38)
Orient
+
Location type
Intronic
Target gene
UBE2Q2
miRNAs that regulate target gene
hsa-mir-32-5p ; hsa-mir-92b-3p ; hsa-mir-331-3p ; hsa-mir-17-5p ; hsa-mir-20a-5p ; hsa-mir-93-5p ; hsa-mir-106b-5p ; hsa-mir-20b-5p ; hsa-mir-519d-3p ; hsa-mir-15a-5p ; hsa-mir-16-5p ; hsa-mir-15b-5p ; hsa-mir-195-5p
Nearest miRNA
hsa-mir-10393/Upstream/129098; hsa-mir-11181/Downstream/3318375;
Nearest TSS
ENST00000557528/Upstream/13227; ENST00000565131/Downstream/12446;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/47229, chr15-CpG: 78/Downstream/12349
Upstream sequence
AAACTTATTATTAGTATGTATAGTGTAGTAAATTAAAAATTATATGTACTTTGAAGTTTTAAAAAATTGAGTTCATGTTATAGAACTAATTCCTGGTAAG
Downstream sequence
CTTTTATGTGCTAGGCTCTAGTCTTTTCATTTATTTTTACTTTTTTTTTTCTCTGTGCCTATGCTTACCAAGTTTTTTTTTTTTAAATCTTTTtattaac
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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