Basic Information
VIS ID
TVIS44011037
Fusion event
HTLV-1-ADAMTSL3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr15
Cytoband
q25.2
Reference genome
GRCh37/hg19
Start
84575417/83906665 (Hg38)
End
84575417/83906665 (Hg38)
Orient
+
Location type
Intronic
Target gene
ADAMTSL3
Nearest miRNA
hsa-mir-10393/Upstream/839250; hsa-mir-11181/Downstream/1473931;
Nearest TSS
ENST00000557528/Upstream/35753; ENST00000567716/Downstream/39070;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/251646, chr15-CpG: 65/Downstream/173176
Upstream sequence
CTGGGAAAACTGGTAATTTTAGTATATGTATCTATATATTTATATAGTGCcacacaccacacacacacacacacacacacacacacacacacacacacac
Downstream sequence
acacacacacacaGAGTTATGGGCTACTTTATTGAACTGTTTTGGTTTTTTCCAAAATTTTTCAGTTAATTTTAGTACTTTTCATAGCTATGTCATTTTC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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