Basic Information
VIS ID
TVIS44011046
Fusion event
HTLV-1-ACSM2B integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr16
Cytoband
p12.3
Reference genome
GRCh37/hg19
Start
20552174/20540852 (Hg38)
End
20552174/20540852 (Hg38)
Orient
-
Location type
Intronic
Target gene
ACSM2B
miRNAs that regulate target gene
hsa-mir-374b-5p ; hsa-mir-374a-5p ; hsa-mir-5692c ; hsa-mir-5692b ; hsa-mir-369-3p ; hsa-mir-8054 ; hsa-mir-548l ; hsa-mir-548k ; hsa-mir-548av-5p ; hsa-mir-559 ; hsa-mir-548y ; hsa-mir-548w ; hsa-mir-548o-5p ; hsa-mir-548j-5p ; hsa-mir-548i ; hsa-mir-548h-5p ; hsa-mir-548d-5p ; hsa-mir-548c-5p ; hsa-mir-548bb-5p ; hsa-mir-548b-5p ; hsa-mir-548ay-5p ; hsa-mir-548au-5p ; hsa-mir-548as-5p ; hsa-mir-548ar-5p ; hsa-mir-548aq-5p ; hsa-mir-548ap-5p ; hsa-mir-548am-5p ; hsa-mir-548ak ; hsa-mir-548ae-5p ; hsa-mir-548ad-5p ; hsa-mir-548ab ; hsa-mir-548a-5p ; hsa-mir-574-5p ; hsa-let-7g-3p ; hsa-let-7a-2-3p ; hsa-mir-6867-5p ; hsa-mir-3177-5p ; hsa-mir-6847-5p ; hsa-mir-4797-5p ; hsa-mir-3191-5p ; hsa-mir-6758-3p
Nearest miRNA
hsa-mir-1225/Upstream/2046276; hsa-mir-11401/Downstream/965197;
Nearest TSS
ENST00000527434/Upstream/58582; ENST00000562852/Downstream/464;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/191676, chr16-CpG: 65/Downstream/200472
Upstream sequence
GATCACAAATGCCTTCACCACCTGCAAAATAGATGAAGGCCAAGAGATAAGGGATTAGAGTGTGTAGTCATCTCCTGGAATAATGTGAAATTAGCATTAA
Downstream sequence
GACTTGCATCACCCTTGTATCTACTCATTTGCACCCCCGGTGATCCAGGTCAAGGGAAAGGGAGAAACTGGGGACAAGAATGAGGTTCCAGCTCTCTCTG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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