Basic Information
VIS ID
TVIS44011048
Fusion event
HTLV-1-SEZ6L2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr16
Cytoband
p11.2
Reference genome
GRCh37/hg19
Start
29905215/29893894 (Hg38)
End
29905215/29893894 (Hg38)
Orient
+
Location type
Intronic
Target gene
SEZ6L2
Nearest miRNA
hsa-mir-1225/Upstream/294629; hsa-mir-11401/Downstream/610025;
Nearest TSS
ENST00000527434/Upstream/5301; ENST00000563177/Downstream/4034;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/16899, chr16-CpG: 50/Downstream/6132
Upstream sequence
cgcttcTGTGCTTTGAAAGTAATAGCagtgactgacagttttgagctctcactgtgtaccacacgctgtttgtgtttttgtttgtttgtttttgagacag
Downstream sequence
agtttcacttttgtcacctagcctggagtacaatggcgcaatctcagctcaatgcaacctccgcctcctgggttcaaacaattctcttgcctcagcctcc
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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