Basic Information
VIS ID
TVIS44011057
Fusion event
HTLV-1-CSNK2A2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr16
Cytoband
q21
Reference genome
GRCh37/hg19
Start
58214964/58181060 (Hg38)
End
58214964/58181060 (Hg38)
Orient
-
Location type
Intronic
Target gene
CSNK2A2
miRNAs that regulate target gene
hsa-mir-1-3p ; hsa-mir-1228-3p
Nearest miRNA
hsa-mir-1225/Upstream/408708; hsa-mir-11401/Downstream/9021261;
Nearest TSS
ENST00000527434/Upstream/13347; ENST00000561923/Downstream/5796;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/51282, chr16-CpG: 141/Downstream/16301
Nearest cancer related gene
CSNK2A2(OG, No orient, 0)
Upstream sequence
atactatctggaaaagaatttaattttcctgccatgatttgctcttcaaaaatacacatctgccatctgatatttaatgatctCTTGATTAAAATGTCAT
Downstream sequence
GGCTTGAACATTCAAAGGGgacctccagttaaacaaggcagatcaaacacctctgctctacctgaaactcctctaaaataaccgtaaaaggagcagggag
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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