Basic Information
VIS ID
TVIS44011062
Fusion event
HTLV-1-WWP2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr16
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
69861626/69827723 (Hg38)
End
69861626/69827723 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA16B
Target gene
WWP2
miRNAs that regulate target gene
hsa-mir-615-3p ; hsa-mir-23b-3p ; hsa-mir-26a-5p ; hsa-let-7a-5p ; hsa-mir-7109-5p ; hsa-mir-6885-5p ; hsa-mir-328-5p ; hsa-mir-6795-5p ; hsa-mir-6887-5p ; hsa-mir-4697-5p ; hsa-mir-4488 ; hsa-mir-1268b ; hsa-mir-1237-5p ; hsa-mir-1268a ; hsa-mir-4731-5p ; hsa-mir-6853-5p ; hsa-mir-637
Nearest miRNA
hsa-mir-1225/Upstream/261855; hsa-mir-11401/Downstream/105358;
Nearest TSS
ENST00000527434/Upstream/28677; ENST00000563618/Downstream/11014;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/65057, chr16-CpG: 77/Downstream/137411
Upstream sequence
GGAGGTTTGTTCTTTGGAAGGTGTTTATAAACATGGCTTTGATACCAGGCAACTGAGAGAGGCGGTTGTGGCCGCTGCGGTTCCCTGAGGGCACAGAGCA
Downstream sequence
TGGGTGATCTGTTGGAGCCAGGCAGGGCCTGGGCAGGGGATTAATGGTGTGGCAGGGACTCTCCCTCCCCTCGGAGATGAGGAGCACTAATGACAAGGCA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate