Basic Information
VIS ID
TVIS44011097
Fusion event
HTLV-1-NAPG integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr18
Cytoband
p11.22
Reference genome
GRCh37/hg19
Start
10551203/10551206 (Hg38)
End
10551203/10551206 (Hg38)
Orient
+
Location type
UTR3
Target gene
NAPG
miRNAs that regulate target gene
hsa-mir-16-5p ; hsa-mir-30a-5p ; hsa-mir-342-3p ; hsa-mir-15a-5p ; hsa-mir-15b-5p ; hsa-mir-126-5p ; hsa-mir-195-5p ; hsa-mir-424-5p ; hsa-mir-497-5p ; hsa-mir-374b-3p ; hsa-mir-944 ; hsa-mir-3646 ; hsa-mir-4524a-5p ; hsa-mir-4524b-5p ; hsa-mir-6838-5p ; hsa-mir-30c-5p ; hsa-mir-30d-5p ; hsa-mir-30b-5p ; hsa-mir-30e-5p ; hsa-mir-499a-3p ; hsa-mir-499b-3p ; hsa-mir-545-5p ; hsa-mir-4477a ; hsa-mir-646 ; hsa-mir-503-5p ; hsa-mir-1252-3p ; hsa-mir-374a-3p ; hsa-mir-361-5p ; hsa-mir-5094
Nearest miRNA
hsa-mir-3976/Upstream/4176781; hsa-mir-1-2/Downstream/208378;
Nearest TSS
ENST00000575820/Upstream/12082; ENST00000579385/Downstream/43384;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/24770, chr18-CpG: 28/Downstream/37946
Upstream sequence
ttattttttttgttgagatggagttgctccatgttgcacaggctgttctcaaactcctaagctcaagccatctgcctgccttggcctcccaaagtgctgg
Downstream sequence
gattgtagacataagccacctcacccagccTATGAATATCTTTCTAACATTGTAAGAATGAGGTAATGTTTCCATCAGTCTAATACAGATATATTTCTTC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate