Basic Information
VIS ID
TVIS44011100
Fusion event
HTLV-1-GREB1L integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr18
Cytoband
q11.1
Reference genome
GRCh37/hg19
Start
18841620/21261659 (Hg38)
End
18841620/21261659 (Hg38)
Orient
-
Location type
Intronic
Target gene
GREB1L
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-mir-18a-3p ; hsa-mir-484 ; hsa-mir-1277-5p ; hsa-mir-190a-3p ; hsa-mir-4789-5p ; hsa-mir-3941 ; hsa-mir-4719 ; hsa-mir-5011-5p ; hsa-mir-4704-5p ; hsa-mir-603 ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-8485
Nearest miRNA
hsa-mir-3156-2/Upstream/6431417; hsa-mir-1-2/Downstream/421859;
Nearest TSS
ENST00000575820/Upstream/19301; ENST00000579454/Downstream/101934;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/18271, chr18-CpG: 107/Downstream/338429
Upstream sequence
TGATTATCTTGTGTTAAAAAAACAAACAAGTAGGCAGAAAACCTCCTTGATCTACCCTAACCTTTCTATATGTAAATTTTGGAAAAGCGACACTGTAGCA
Downstream sequence
TGCCAATAAAATTTACTCCTGCATTGACATTTCCAAAGTAATTATAAAAAGGATTATAAAATTTACTAAAGGAATTGCTATTTGTTGGTTGACAAAATTT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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