Basic Information
VIS ID
TVIS44011121
Fusion event
HTLV-1-ELL integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr19
Cytoband
p13.11
Reference genome
GRCh37/hg19
Start
18556134/18445324 (Hg38)
End
18556134/18445324 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA19B
Target gene
ELL
miRNAs that regulate target gene
hsa-mir-769-3p ; hsa-mir-1321 ; hsa-mir-149-3p ; hsa-mir-27a-5p ; hsa-mir-3065-5p ; hsa-mir-3131 ; hsa-mir-3153 ; hsa-mir-4270 ; hsa-mir-4327 ; hsa-mir-4417 ; hsa-mir-4441 ; hsa-mir-4668-5p ; hsa-mir-4728-5p ; hsa-mir-4739 ; hsa-mir-4756-5p ; hsa-mir-5004-5p ; hsa-mir-541-3p ; hsa-mir-611 ; hsa-mir-6134 ; hsa-mir-654-5p ; hsa-mir-6733-5p ; hsa-mir-6739-5p ; hsa-mir-6754-5p ; hsa-mir-6785-5p ; hsa-mir-6877-5p ; hsa-mir-6883-5p ; hsa-mir-7-1-3p ; hsa-mir-7-2-3p ; hsa-mir-7706
Nearest miRNA
hsa-mir-10395/Upstream/58690; hsa-let-7e/Downstream/989739;
Nearest TSS
ENST00000633603/Upstream/3905; ENST00000597837/Downstream/75;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/6973, chr19-CpG: 24/Downstream/904
Nearest cancer related gene
ELL(OG, No orient, 0)
Upstream sequence
TTTTTGATTTTTCGATATTCCTGCAAAATCTGCCCTCGAGTAGTCTAGAAGAAAAACAAAATTTTGAGAAAACAGAATGTGTCCCCGCCTACAGGAAACC
Downstream sequence
CAAATTGAGTGGTCCCAGGTGCTCTGAGAAGGGGGCATGGGAGGGTGGGGCAGCCTCAAGGACAAGGCCAAGTAACACCCCAGGGGCCCACAGCGGCTGT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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