Basic Information
VIS ID
TVIS44011122
Fusion event
HTLV-1-ZNF254 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr19
Cytoband
p12
Reference genome
GRCh37/hg19
Start
24278250/24095448 (Hg38)
End
24278250/24095448 (Hg38)
Orient
-
Location type
Intronic
Target gene
ZNF254
miRNAs that regulate target gene
hsa-mir-155-5p ; hsa-mir-365b-3p ; hsa-mir-365a-3p ; hsa-mir-216a-5p ; hsa-mir-3974 ; hsa-mir-5692a ; hsa-mir-629-3p ; hsa-mir-183-3p ; hsa-mir-519e-5p ; hsa-mir-515-5p ; hsa-mir-3925-3p ; hsa-mir-766-3p ; hsa-mir-770-5p ; hsa-mir-4712-5p ; hsa-mir-200b-5p ; hsa-mir-200a-5p ; hsa-mir-26b-5p ; hsa-mir-26a-5p
Nearest miRNA
hsa-mir-10395/Upstream/3696094; hsa-let-7e/Downstream/11027252;
Nearest TSS
ENST00000633603/Upstream/8195; ENST00000593783/Downstream/8738;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/123491, chr19-CpG: 42/Downstream/3698172
Upstream sequence
gtttgttttatctttgccaggttttggtatcagaatagtgctgttcttatataatgagttgaaaacaagttactttttcttaattgcttaaaatagtttc
Downstream sequence
tgtagaaataataatcagcacttttttgtacatctgatagaattcagctgtgaatctgtctggtccttggctttgtttggttggtaggctatttattact
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate