Basic Information
VIS ID
TVIS44011126
Fusion event
HTLV-1-CEP89 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr19
Cytoband
q13.11
Reference genome
GRCh37/hg19
Start
33448376/32957470 (Hg38)
End
33448376/32957470 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA19A
Target gene
CEP89
miRNAs that regulate target gene
hsa-mir-193a-3p ; hsa-mir-6842-3p ; hsa-mir-6807-5p ; hsa-mir-7151-3p ; hsa-mir-5095 ; hsa-mir-4430 ; hsa-mir-3652 ; hsa-mir-3922-3p ; hsa-mir-3176 ; hsa-mir-4433a-3p ; hsa-mir-6504-3p ; hsa-mir-889-5p ; hsa-mir-4433b-3p ; hsa-mir-4700-3p ; hsa-mir-7153-3p ; hsa-mir-6749-3p ; hsa-mir-1260b ; hsa-mir-1260a ; hsa-mir-532-3p ; hsa-mir-4726-3p ; hsa-mir-6764-5p ; hsa-mir-1915-3p ; hsa-mir-6840-3p ; hsa-mir-1224-3p ; hsa-mir-484 ; hsa-mir-3155b ; hsa-mir-3155a ; hsa-mir-6513-3p ; hsa-mir-4714-3p ; hsa-mir-8079 ; hsa-mir-1245a ; hsa-mir-5698 ; hsa-mir-7156-3p ; hsa-mir-143-5p ; hsa-mir-3622b-5p ; hsa-mir-6499-3p ; hsa-mir-1184 ; hsa-mir-1304-3p ; hsa-mir-103b ; hsa-mir-5693 ; hsa-mir-6890-3p ; hsa-mir-7705 ; hsa-mir-6854-5p ; hsa-mir-509-5p ; hsa-mir-509-3-5p ; hsa-mir-4418 ; hsa-mir-656-5p ; hsa-mir-122-5p ; hsa-mir-504-3p ; hsa-mir-3135b ; hsa-mir-6765-3p
Nearest miRNA
hsa-mir-10395/Upstream/12558116; hsa-let-7e/Downstream/2165230;
Nearest TSS
ENST00000633603/Upstream/79049; ENST00000590281/Downstream/2482;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/236296, chr19-CpG: 48/Downstream/14339
Upstream sequence
AATTGAGTGTATGTGCGTGCATGAGCAtggctcacacctataatcccgcactttgggaggccaaggagagaggatctcttgaagctagaagttcaagtcc
Downstream sequence
agcctgggtaatatcaggaaaccctgtctctacaaaataaaaataaaaattagcctgggctgggcacagtggttcatgcctgtcatcccagcactttggg
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate