Basic Information
VIS ID
TVIS44011136
Fusion event
HTLV-1-EHD3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
p23.1
Reference genome
GRCh37/hg19
Start
31481341/31258475 (Hg38)
End
31481341/31258475 (Hg38)
Orient
-
Location type
Intronic
Target gene
EHD3
miRNAs that regulate target gene
hsa-mir-7-5p ; hsa-mir-573 ; hsa-mir-5706 ; hsa-mir-3616-5p ; hsa-mir-4782-5p ; hsa-mir-516b-5p ; hsa-mir-1299 ; hsa-mir-139-3p ; hsa-mir-4524a-3p ; hsa-mir-4795-5p ; hsa-mir-4635 ; hsa-mir-513c-3p ; hsa-mir-513a-3p ; hsa-mir-3606-3p ; hsa-mir-574-5p ; hsa-mir-675-3p ; hsa-mir-6867-5p ; hsa-mir-223-5p ; hsa-mir-586 ; hsa-mir-6516-3p ; hsa-mir-4732-5p ; hsa-mir-6832-5p ; hsa-mir-3659 ; hsa-mir-3668 ; hsa-mir-5586-3p ; hsa-mir-7110-3p ; hsa-mir-4522 ; hsa-mir-3664-5p ; hsa-mir-7156-3p ; hsa-mir-7843-3p ; hsa-mir-4786-3p ; hsa-mir-1184 ; hsa-mir-1976 ; hsa-mir-3653-5p ; hsa-mir-6893-3p ; hsa-mir-370-3p ; hsa-mir-8060 ; hsa-mir-6865-3p ; hsa-mir-6877-3p ; hsa-mir-6819-3p ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-8485 ; hsa-mir-7109-3p ; hsa-mir-3672 ; hsa-mir-4277 ; hsa-mir-5584-3p ; hsa-mir-627-3p ; hsa-mir-6844 ; hsa-mir-6864-3p
Nearest miRNA
hsa-mir-1301/Upstream/3262026; hsa-mir-10b/Downstream/1273678;
Nearest TSS
ENST00000437798/Upstream/24138; ENST00000435713/Downstream/125920;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/23688, chr2-CpG: 99/Downstream/321748
Nearest cancer related gene
EHD3(TSG, No orient, 0)
Upstream sequence
GGGTGTTCACTAGATGCCACAGGGTGGGGGAAAGGCTTTTTAAACCTAGCTCCGTTGGCTCCATTCATCCTCATCCCCCACCCCATCGATGCCTGCTACT
Downstream sequence
TAGTCTGAAATGACAGCCTTTGAAAGTGAAAGCCAACTCGGTGCagtggttcatagcactgactccagggctaccttcctggacttgagtcccagcccat
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate