Basic Information
VIS ID
TVIS44011145
Fusion event
HTLV-1-ASB3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
p16.2
Reference genome
GRCh37/hg19
Start
53993676/53766539 (Hg38)
End
53993676/53766539 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA2S ; FRA2D ; FRA2H
Target gene
ASB3
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-935 ; hsa-mir-615-3p ; hsa-mir-30a-5p ; hsa-mir-30c-5p ; hsa-mir-30d-5p ; hsa-mir-30b-5p ; hsa-mir-30e-5p ; hsa-mir-342-3p ; hsa-mir-1285-5p ; hsa-mir-193b-3p ; hsa-mir-193a-3p ; hsa-mir-204-3p ; hsa-mir-2681-5p ; hsa-mir-4646-5p ; hsa-mir-4747-5p ; hsa-mir-5196-5p ; hsa-mir-7849-3p
Nearest miRNA
hsa-mir-1301/Upstream/1063924; hsa-mir-10b/Downstream/82583;
Nearest TSS
ENST00000437798/Upstream/978; ENST00000295304/Downstream/987;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/1136553, chr2-CpG: 28/Downstream/1215
Upstream sequence
GTGATAATGGCATCACAGTTATTAGGAGAATGCCCTTATTCTTTTTTTTTAGGGAACTTGTTCtaggatgaatgtccttattcttatgagacacatgtag
Downstream sequence
agtatgtggcagtaaaatgtcataacacaagcaacttcaaatgttctccatttaaaagtataaataaagtaaaaaggaagtacagcaactgtgcaaaatg
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate