Basic Information
VIS ID
TVIS44011147
Fusion event
HTLV-1-chr2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
p15
Reference genome
GRCh37/hg19
Start
62687869/62460734 (Hg38)
End
62687869/62460734 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA2S
Target gene
LOC105374764 ; TMEM17
miRNAs that regulate target gene
hsa-mir-192-5p
Nearest miRNA
hsa-mir-1301/Upstream/254817; hsa-mir-10b/Downstream/1880013;
Nearest TSS
ENST00000437798/Upstream/245216; ENST00000416845/Downstream/2393;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/3317, chr2-CpG: 79/Downstream/44889
Nearby gene
TMEM17(-39487) ;
Upstream sequence
TATCAGATAAACTTAAGAACAGGCATTTTAGTCCTGAAGGTCGCATTTTTTCCCAGTCATTATTTTTATAAATAGTGAAATAAACTCTGAGATAAAGTCC
Downstream sequence
TTTTAATATGGGCTGCACATGTCCCCTCCTTAGCACTTTTGTCTCCAGACAAAACCTTTTGAACTGGAACCCTTGCCTCATTCAATGCTATTTTCGattt
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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