Basic Information
VIS ID
TVIS44011152
Fusion event
HTLV-1-ALMS1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
p13.1
Reference genome
GRCh37/hg19
Start
73823001/73595874 (Hg38)
End
73823001/73595874 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA2S ; FRA2E
Target gene
ALMS1
miRNAs that regulate target gene
hsa-mir-197-3p ; hsa-mir-375 ; hsa-mir-21-5p ; hsa-mir-99b-3p ; hsa-mir-92a-3p ; hsa-mir-22-3p ; hsa-mir-218-5p
Nearest miRNA
hsa-mir-1285-2/Upstream/3342869; hsa-mir-10b/Downstream/1494938;
Nearest TSS
ENST00000437798/Upstream/75929; ENST00000464408/Downstream/4961;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/209341, chr2-CpG: 31/Downstream/141317
Upstream sequence
tccacttccttgtcaacacttgctattgtccacctttttatttatagccattctagtgggtgtgaagtggtatcttattgtgagtttaatttgaatttcc
Downstream sequence
ctaatgactgatgatgttgaacattttgtgtgcttattggccactcttacatcttctttgatgaagtgtctttttaaatctttttgcccattttaaaatt
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate