Basic Information
VIS ID
TVIS44011175
Fusion event
HTLV-1-NCKAP5 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
q21.2
Reference genome
GRCh37/hg19
Start
134289157/133531586 (Hg38)
End
134289157/133531586 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA2S
Target gene
NCKAP5
miRNAs that regulate target gene
hsa-mir-130b-3p ; hsa-mir-19b-3p ; hsa-mir-7977 ; hsa-mir-6892-5p ; hsa-mir-3925-3p ; hsa-mir-4267 ; hsa-mir-5588-3p ; hsa-mir-4475 ; hsa-mir-518e-3p
Nearest miRNA
hsa-mir-1285-2/Upstream/1097766; hsa-mir-10b/Downstream/595539;
Nearest TSS
ENST00000437798/Upstream/4401; ENST00000420184/Downstream/22729;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/264691, chr2-CpG: 22/Downstream/478208
Upstream sequence
TCTGGTTCTAAATGTGCTTATTTTTTTCTACTGGATTTTTTTACATAGAAAATTGCAACGTTTTTGGCTTTTCCTGTCCGATACTTACAAGTCTTGTTTC
Downstream sequence
ATTTTCTGGTCATACAGCATTGACCAGGGAAGCAAGTTTTTAGCAGAAACTTTTGCTCCTGACTTCAGTAGAATTAGTAGTAATGTTTTTATCCATAAGA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate