Basic Information
VIS ID
TVIS44011180
Fusion event
HTLV-1-MARCH7 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
q24.2
Reference genome
GRCh37/hg19
Start
160576424/159719913 (Hg38)
End
160576424/159719913 (Hg38)
Orient
-
Location type
Intronic
Target gene
MARCH7
miRNAs that regulate target gene
hsa-mir-411-5p ; hsa-mir-6829-3p ; hsa-mir-6791-3p ; hsa-mir-1976 ; hsa-mir-3653-5p ; hsa-mir-6747-3p ; hsa-mir-6727-3p ; hsa-mir-4722-3p
Nearest miRNA
hsa-mir-128-1/Upstream/533012; hsa-mir-10b/Downstream/687897;
Nearest TSS
ENST00000437798/Upstream/7390; ENST00000461582/Downstream/14052;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/6745, chr2-CpG: 69/Downstream/77805
Upstream sequence
cagattagagactgagataaacaatatttatgcattgatatgggcatattcttctgtcggggcattagtatggtgggttgactttgttttgtctgtagtc
Downstream sequence
gagatggatatgacctttattattgctttatttaccttcagagtattccagtagtggactgccgctgcctagtgcttagtatgaggccaagaatgttgga
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate