Basic Information
VIS ID
TVIS44011181
Fusion event
HTLV-1-RBMS1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
q24.2
Reference genome
GRCh37/hg19
Start
161260256/160403745 (Hg38)
End
161260256/160403745 (Hg38)
Orient
+
Location type
Intronic
Target gene
RBMS1
miRNAs that regulate target gene
hsa-mir-30a-5p ; hsa-mir-124-3p ; hsa-mir-16-5p ; hsa-mir-1249-3p ; hsa-mir-4662a-5p ; hsa-mir-325 ; hsa-mir-3976 ; hsa-mir-6856-5p ; hsa-mir-6758-5p
Nearest miRNA
hsa-mir-128-1/Upstream/1216844; hsa-mir-10b/Downstream/4065;
Nearest TSS
ENST00000437798/Upstream/36219; ENST00000477952/Downstream/4144;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/133338, chr2-CpG: 104/Downstream/3534
Upstream sequence
AGACCATTAAacacacacagatataaacacacacatacacacatgcaGAAAAATTTTGCATTCACTCCCCTACCTCCAAAACCCTACTGGAAACCACTAG
Downstream sequence
GACAACATACTGCTTAGCAAAAAAGGCCTTCCTACATGCCACGATGTGCAGAAACCAAAGTATGGTTGGTTTGTAACTTAGCTACCTCAAGAAAGCAGTT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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