Basic Information
VIS ID
TVIS44011188
Fusion event
HTLV-1-BARD1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
q35
Reference genome
GRCh37/hg19
Start
215648990/214784266 (Hg38)
End
215648990/214784266 (Hg38)
Orient
+
Location type
Intronic
Target gene
BARD1
miRNAs that regulate target gene
hsa-mir-192-5p ; hsa-mir-193b-3p ; hsa-mir-215-5p ; hsa-mir-182-5p ; hsa-mir-3942-3p ; hsa-mir-6802-3p ; hsa-mir-610 ; hsa-mir-6501-3p ; hsa-mir-500b-3p ; hsa-mir-4760-3p
Nearest miRNA
hsa-mir-10b/Upstream/1026107; hsa-mir-1244-1/Downstream/3116247;
Nearest TSS
ENST00000437798/Upstream/31788; ENST00000420134/Downstream/25376;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/1499564, chr2-CpG: 110/Downstream/25005
Nearest cancer related gene
BARD1(TSG, No orient, 0)
Upstream sequence
agaacttaaacaaatttacaagaaaaaatcaaccccatcaaaaagtgggcgaaggatataaacagatacttctcaaaagaagacatttatgtggccaaca
Downstream sequence
aacacgaaaaaaaagctcatcatcatcattagacaaatgcaaatcaaaaccacaatgagatatcatctcacgccagttagaatggcgatcattaaaaagt
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate