Basic Information
VIS ID
TVIS44011211
Fusion event
HTLV-1-TOX2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr20
Cytoband
q13.12
Reference genome
GRCh37/hg19
Start
42695859/44067219 (Hg38)
End
42695859/44067219 (Hg38)
Orient
+
Location type
Intronic
Target gene
TOX2
miRNAs that regulate target gene
hsa-mir-335-5p
Nearest miRNA
hsa-mir-103a-2/Upstream/2898141; hsa-mir-1-1/Downstream/340901;
Nearest TSS
ENST00000382410/Upstream/12868; ENST00000435163/Downstream/119874;
Nearest CpG islands
None/Target, chr20-CpG: 39/Upstream/150722, chr20-CpG: 79/Downstream/48463
Upstream sequence
CAAGTGCTTCCACGTGACATTCACAGATGAGTCCTGCAtcttaggccagttccctagaagcagagcctgaggcagcagggattgggtgcctttggggatg
Downstream sequence
cactggggaaagcttgcaggagaagggggtgagggaggcaggacagggtgggggaaggagctgaggggggatgtggcctcagctgaagacttgcttctgc
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate