Basic Information
VIS ID
TVIS44011216
Fusion event
HTLV-1-NFATC2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr20
Cytoband
q13.2
Reference genome
GRCh37/hg19
Start
50042016/51425479 (Hg38)
End
50042016/51425479 (Hg38)
Orient
-
Location type
Intronic
Target gene
NFATC2
miRNAs that regulate target gene
hsa-mir-184 ; hsa-mir-526b-5p ; hsa-mir-7157-5p ; hsa-mir-4310 ; hsa-mir-451b ; hsa-mir-5571-5p ; hsa-mir-4512 ; hsa-mir-3157-5p ; hsa-mir-20b-3p ; hsa-mir-1304-3p ; hsa-mir-1208 ; hsa-mir-6760-3p ; hsa-mir-1183 ; hsa-mir-10a-3p ; hsa-mir-466 ; hsa-mir-4672 ; hsa-mir-3941 ; hsa-mir-496 ; hsa-mir-6504-3p ; hsa-mir-4700-3p ; hsa-mir-8485 ; hsa-mir-4459 ; hsa-mir-603 ; hsa-mir-129-5p ; hsa-mir-489-3p ; hsa-mir-514a-3p ; hsa-mir-514b-3p
Nearest miRNA
hsa-mir-103a-2/Upstream/810694; hsa-mir-1-1/Downstream/27426;
Nearest TSS
ENST00000382410/Upstream/26260; ENST00000454600/Downstream/117240;
Nearest CpG islands
None/Target, chr20-CpG: 39/Upstream/401804, chr20-CpG: 43/Downstream/66778
Nearest cancer related gene
NFATC2(TSG, No orient, 0)
Upstream sequence
GTACCAGCAAGGCCTACGCTGAGATACTCAGACCGGGCTCTCCAGGTGCCCACAGCCTCTGGGCCACTTGGCTGGGCAACTGCCTGGCTCAGTTCTCATC
Downstream sequence
AGCACAGAGACTCCCTGTGTCTCACCCTCTGTCGGCACCAGGAGGCCCAGCCCTGCCGGGGTCATCGTGGCTGCCGGGCTCACGGCAGGGCTCTGCGGTG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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