Basic Information
VIS ID
TVIS44011217
Fusion event
HTLV-1-ZFP64 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr20
Cytoband
q13.2
Reference genome
GRCh37/hg19
Start
50804788/52188249 (Hg38)
End
50804788/52188249 (Hg38)
Orient
-
Location type
Intronic
Target gene
ZFP64
miRNAs that regulate target gene
hsa-mir-320a ; hsa-mir-196a-5p ; hsa-mir-138-1-3p ; hsa-mir-421 ; hsa-mir-505-3p ; hsa-mir-7159-5p ; hsa-mir-4433a-3p ; hsa-mir-4459 ; hsa-mir-4768-3p ; hsa-mir-6500-3p ; hsa-mir-3614-5p ; hsa-mir-3679-3p ; hsa-mir-514b-5p ; hsa-mir-513c-5p ; hsa-mir-4286 ; hsa-mir-361-3p ; hsa-mir-483-3p
Nearest miRNA
hsa-mir-103a-2/Upstream/735272; hsa-mir-1-1/Downstream/1880159;
Nearest TSS
ENST00000382410/Upstream/12212; ENST00000454600/Downstream/3448;
Nearest CpG islands
None/Target, chr20-CpG: 39/Upstream/35580, chr20-CpG: 115/Downstream/3010
Upstream sequence
aAGATCCCTATGGGCTCTGCCCTTTACTTCACTGATTTCCCTGATTCAACACTGCaatcaatcaattccagatttcattaggccagtataatttgggttt
Downstream sequence
ctgctacttgtagccaaaattcattcctaactgGCAGGGACATTATTTCtttttctttcttttttttttttttttttttttttgagacagagtcttgctc
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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