Basic Information
VIS ID
TVIS44011223
Fusion event
HTLV-1-LOC388813 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr21
Cytoband
q11.2
Reference genome
GRCh37/hg19
Start
16002184/14629863 (Hg38)
End
16002184/14629863 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA21A
Target gene
LOC388813
Nearest miRNA
hsa-mir-10396a/Upstream/905589; hsa-let-7c/Downstream/1909226;
Nearest TSS
ENST00000624081/Upstream/13847; ENST00000430391/Downstream/13270;
Nearest CpG islands
None/Target, chr21-CpG: 261/Upstream/246098, chr21-CpG: 171/Downstream/434312
Upstream sequence
AATCCTAAAGCAACAAACTCTTCTCAGAGCACTATAAATATCCAGGATGGCAAAACAGGTTACCTAGGGGATGGTTATTTGCATTATAAAAGATTCCTCC
Downstream sequence
TTTGCAAAAAGATTCCCTTCCAGATGTCTTAAAACAGAGGTCTCTTAAGTGTCCTTAAATGTGATTTATAAAATTATATTTACACAAGGTTTTAGAAAGG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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