Basic Information
VIS ID
TVIS44011227
Fusion event
HTLV-1-MIR548XHG integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr21
Cytoband
q21.1
Reference genome
GRCh37/hg19
Start
19968255/18595937 (Hg38)
End
19968255/18595937 (Hg38)
Orient
-
Location type
ncRNA_intronic
Target gene
MIR548XHG
Nearest miRNA
hsa-let-7c/Upstream/2005612; hsa-mir-155/Downstream/90153;
Nearest TSS
ENST00000624081/Upstream/110058; ENST00000416002/Downstream/18494;
Nearest CpG islands
None/Target, chr21-CpG: 261/Upstream/350380, chr21-CpG: 89/Downstream/2401168
Upstream sequence
gtgatcttggctttctgtttatatttaagagaagggtgaaaaaaaatacatatctgacatgagaccagtatgaatgggctgggattatgggctgataagc
Downstream sequence
ctaaggatcacctgttggtaaatgggcactccacttagattcccttaaacgtcagtatcatatgtaatttctctcgtactagatgtccatatttttcctg
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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