Basic Information
VIS ID
TVIS44011231
Fusion event
HTLV-1-N6AMT1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr21
Cytoband
q21.3
Reference genome
GRCh37/hg19
Start
29815611/28443290 (Hg38)
End
29815611/28443290 (Hg38)
Orient
-
Location type
Intronic
Target gene
N6AMT1
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-mir-99a-5p ; hsa-mir-183-3p ; hsa-mir-3120-5p ; hsa-mir-20b-3p ; hsa-mir-4680-3p ; hsa-mir-5187-3p ; hsa-mir-4427 ; hsa-mir-5699-3p ; hsa-mir-4421 ; hsa-mir-6748-3p ; hsa-mir-4478 ; hsa-mir-4419b ; hsa-mir-3929
Nearest miRNA
hsa-let-7c/Upstream/1489247; hsa-mir-3197/Downstream/1932004;
Nearest TSS
ENST00000624081/Upstream/214623; ENST00000412526/Downstream/96028;
Nearest CpG islands
None/Target, chr21-CpG: 261/Upstream/1299303, chr21-CpG: 29/Downstream/441813
Nearby gene
LINC00161(+96029) ;
Upstream sequence
AAATTATGACATTCTCAAACTGGATAATTGGAGTTCAATAAAACACCTATTTCTAAAAGTATGGATAAAGCTAAAAATGGTAGCTCAAATAATAGTAAAA
Downstream sequence
TACCTCTTTCTTGCAACCTCTGATAGGCAATTGCTCctctggtttggaaactgtcccttccagaactcatgctgaaatgcagttgctattgtgacagtat
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate