Basic Information
VIS ID
TVIS44011240
Fusion event
HTLV-1-C2CD2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr21
Cytoband
q22.3
Reference genome
GRCh37/hg19
Start
43343765/41923656 (Hg38)
End
43343765/41923656 (Hg38)
Orient
-
Location type
Intronic
Target gene
C2CD2
miRNAs that regulate target gene
hsa-mir-193b-3p ; hsa-mir-10a-5p ; hsa-mir-510-3p ; hsa-mir-4680-5p ; hsa-mir-499b-5p ; hsa-mir-4738-3p ; hsa-mir-4494 ; hsa-mir-5582-5p ; hsa-mir-4691-5p ; hsa-mir-6792-3p ; hsa-mir-6794-3p ; hsa-mir-9-3p ; hsa-mir-136-5p ; hsa-mir-483-3p ; hsa-mir-4429 ; hsa-mir-320d ; hsa-mir-320c ; hsa-mir-320b ; hsa-mir-320a
Nearest miRNA
hsa-let-7c/Upstream/176815; hsa-mir-5692b/Downstream/1027272;
Nearest TSS
ENST00000624081/Upstream/4623; ENST00000412906/Downstream/3016;
Nearest CpG islands
None/Target, chr21-CpG: 261/Upstream/15741, chr21-CpG: 144/Downstream/29370
Upstream sequence
ACATACAAAGTATCAAACAATTATAAAATTATGCAGCCGTACCAAAACCAGAATTATAAAATGAGCTCGTTGAAGAAACTGTCAGACAGAGAAAGATAAT
Downstream sequence
AACCTCAGGAATAAACCAAACTGTGGTTTCCTGACATAAATCATAATCATACAGTATTAAGAGGGGTGCTTTTCACAGCTACCATGGCACAGAGAGAGAT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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