Basic Information
VIS ID
TVIS44011248
Fusion event
HTLV-1-APOL5 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr22
Cytoband
q12.3
Reference genome
GRCh37/hg19
Start
36109919/35713872 (Hg38)
End
36109919/35713872 (Hg38)
Orient
-
Location type
Intronic
Target gene
APOL5
Nearest miRNA
hsa-mir-1286/Upstream/377073; hsa-let-7a-3/Downstream/572975;
Nearest TSS
ENST00000624155/Upstream/27932; ENST00000249044/Downstream/4000;
Nearest CpG islands
None/Target, chr22-CpG: 279/Upstream/161923, chr22-CpG: 131/Downstream/314299
Nearby gene
APOL5(+4000) ;
Upstream sequence
CCAGCTCACTGTCCCCACCTACAACGGGAGATGCTAGAGATTATGAAGTGACTTGAGGCACTGGATGTGGCTGATCCTGGGTCCGAAAGTGAAGGTGAGG
Downstream sequence
AACTAAAGTCCCTTTCTTGCCCTATCTCCCATGAGATTCTGCTCACACTCCTCCTACAATTAGAGACCTCTCATCCTGGGTTCCTTAGCTGTGGTGACTG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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