Basic Information
VIS ID
TVIS44011264
Fusion event
HTLV-1-PXK integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
p14.3
Reference genome
GRCh37/hg19
Start
58340162/58354435 (Hg38)
End
58340162/58354435 (Hg38)
Orient
-
Location type
Intronic
Target gene
PXK
miRNAs that regulate target gene
hsa-mir-744-5p ; hsa-mir-4503 ; hsa-mir-488-3p ; hsa-mir-6792-5p ; hsa-mir-6730-5p ; hsa-mir-5681a ; hsa-mir-501-5p ; hsa-mir-500a-5p ; hsa-mir-519c-3p ; hsa-mir-519b-3p ; hsa-mir-519a-3p ; hsa-mir-4796-3p ; hsa-mir-548ah-5p ; hsa-mir-3609 ; hsa-mir-93-5p ; hsa-mir-106a-5p ; hsa-mir-106b-5p ; hsa-mir-20b-5p ; hsa-mir-17-5p ; hsa-mir-20a-5p ; hsa-mir-519d-3p ; hsa-mir-526b-3p ; hsa-mir-3666 ; hsa-mir-4295 ; hsa-mir-301b-3p ; hsa-mir-130a-3p ; hsa-mir-130b-3p ; hsa-mir-454-3p ; hsa-mir-301a-3p ; hsa-mir-4309 ; hsa-mir-3198 ; hsa-mir-4653-3p ; hsa-mir-101-5p ; hsa-mir-548p ; hsa-mir-577 ; hsa-mir-513b-3p ; hsa-mir-4662a-3p ; hsa-mir-548m ; hsa-mir-489-3p ; hsa-mir-526b-5p ; hsa-mir-578
Nearest miRNA
hsa-let-7g/Upstream/2501841; hsa-mir-12124/Downstream/2263370;
Nearest TSS
ENST00000440867/Upstream/21129; ENST00000459676/Downstream/41239;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/20970, chr3-CpG: 67/Downstream/79014
Upstream sequence
GGAGATATGGGTGAGAGTAGAGGAGATTATGAGGTTTGGTTGGTGGTTGCGTCATCTGTTTCCTTCCACTCATGCAAGGTTTTTTATTTTTGTGGTGTGG
Downstream sequence
AGCTGCTTCCTAGttttttttttttttttgagactgagtctctcactctgtcacaggctggagtgcagtggcctgatctcagctcactgcaacctccacc
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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