Basic Information
VIS ID
TVIS44011301
Fusion event
HTLV-1-ADIPOQ integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
q27.3
Reference genome
GRCh37/hg19
Start
186575001/186857212 (Hg38)
End
186575001/186857212 (Hg38)
Orient
+
Location type
UTR3
Fragile sites / regions
FRA3C
Target gene
ADIPOQ
miRNAs that regulate target gene
hsa-mir-6513-5p ; hsa-mir-887-5p ; hsa-mir-3913-5p ; hsa-mir-3122 ; hsa-mir-450a-1-3p ; hsa-mir-6780a-5p ; hsa-mir-6779-5p ; hsa-mir-3689c ; hsa-mir-3689b-3p ; hsa-mir-3689a-3p ; hsa-mir-30b-3p ; hsa-mir-1273h-5p ; hsa-mir-6788-5p ; hsa-mir-30c-2-3p ; hsa-mir-30c-1-3p ; hsa-mir-6514-3p ; hsa-mir-3165 ; hsa-mir-6745 ; hsa-mir-363-5p ; hsa-mir-6799-5p ; hsa-mir-6883-5p ; hsa-mir-6785-5p ; hsa-mir-4728-5p ; hsa-mir-149-3p ; hsa-mir-7106-5p ; hsa-mir-3656 ; hsa-mir-6811-3p ; hsa-mir-214-5p ; hsa-mir-6087 ; hsa-mir-383-3p
Nearest miRNA
hsa-let-7g/Upstream/70435; hsa-mir-28/Downstream/1831569;
Nearest TSS
ENST00000440867/Upstream/1089; ENST00000487031/Downstream/73273;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/29530, chr3-CpG: 81/Downstream/73173
Upstream sequence
catcatgttttctggtgatgcccaaagaggagagaggaagctctctttcccagatgccccagcaagtgtaaccttgcatctcattgctctggctgagttg
Downstream sequence
tgtgcctgtttctgaccaatcactgagtcaggaggatgaaatattcatattgacttaATTGCAGCTTAAGTTAGGGGTATGTAGAGGTATTttccctaaa
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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