Basic Information
VIS ID
TVIS44011305
Fusion event
HTLV-1-RGS12 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
p16.3
Reference genome
GRCh37/hg19
Start
3325229/3323502 (Hg38)
End
3325229/3323502 (Hg38)
Orient
+
Location type
Intronic
Target gene
RGS12
miRNAs that regulate target gene
hsa-mir-149-5p ; hsa-mir-138-5p ; hsa-mir-7704 ; hsa-mir-4532 ; hsa-mir-4726-3p ; hsa-mir-6764-5p ; hsa-mir-1915-3p ; hsa-mir-6840-3p ; hsa-mir-665 ; hsa-mir-4459
Nearest miRNA
hsa-mir-4800/Upstream/1073346; hsa-mir-12113/Downstream/2599773;
Nearest TSS
ENST00000502981/Upstream/5463; ENST00000643191/Downstream/18913;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/6101, chr4-CpG: 17/Downstream/16554
Upstream sequence
CTGCAGTTCAGAGTTCGCTTCCTTTCATGGACTTACTCTGTTTGCACAGGCTCTtggatattctcttccttttccttccctttattgaaaatacatgtga
Downstream sequence
catactgctgtgagttacttttttctaaaacaaatttctcatgtacatagttatatatcaattttaaaaactcttcttcattgtagtggccacgtggtat
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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