Basic Information
VIS ID
TVIS44011306
Fusion event
HTLV-1-LOC105374493 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
p15.33
Reference genome
GRCh37/hg19
Start
12936445/12934821 (Hg38)
End
12936445/12934821 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA4D
Target gene
LOC105374493
Nearest miRNA
hsa-mir-12113/Upstream/1151573; hsa-mir-12115/Downstream/693044;
Nearest TSS
ENST00000502981/Upstream/69860; ENST00000510907/Downstream/13849;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/1505189, chr4-CpG: 97/Downstream/549077
Nearby gene
RAB28(-432902) ;
Upstream sequence
GAGTTTCTCACCATGGCATGAAATACCAGATACATTCACTCTGCAGACAGGAaacaatagttaccatttattcgatgccttccatgtgttgtattctata
Downstream sequence
taaagctctttgcaggtatcatctctttaattttcataagacctctgtgagtcagaaattattTTAAATTTGTGCATACTCTGCTAGAGCCCCAAAAGGA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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