Basic Information
VIS ID
TVIS44011307
Fusion event
HTLV-1-LINC02438 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
p15.31
Reference genome
GRCh37/hg19
Start
19451391/19449768 (Hg38)
End
19451391/19449768 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA4D
Target gene
LINC02438
Nearest miRNA
hsa-mir-12113/Upstream/5821811; hsa-mir-12115/Downstream/1078507;
Nearest TSS
ENST00000502981/Upstream/960260; ENST00000511431/Downstream/5668;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/1427118, chr4-CpG: 284/Downstream/801885
Nearby gene
SLIT2(+802137) ;
Upstream sequence
tttaagatactttttgtgaaatatgtaaggtctctgcttggatcctttttcttccccctgtggatgtccagtggtgctagcaccacttcttggaaagaca
Downstream sequence
atcttggcttcattgtatttcctttgatactttgtaaaagacaaattgactaCACAATTGATCCTTGAAGAACACAGAGGTTAGGGTCACtgtattagtc
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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