Basic Information
VIS ID
TVIS44011332
Fusion event
HTLV-1-LOC105377378 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
q26
Reference genome
GRCh37/hg19
Start
115270333/114349177 (Hg38)
End
115270333/114349177 (Hg38)
Orient
-
Location type
Intronic
Target gene
LOC105377378
Nearest miRNA
hsa-mir-12113/Upstream/1196815; hsa-mir-1305/Downstream/307582;
Nearest TSS
ENST00000502981/Upstream/369450; ENST00000507710/Downstream/249278;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/369523, chr4-CpG: 122/Downstream/249089
Nearby gene
UGT8(+249278) ;
Upstream sequence
AAATTAGCCTCCCAAAATTACGGAGGTTAAATATTTCTGCTTAAAAATAAAAATGAAAATCGTATACCTTGCCTTGAAATCATTAGTTCACCAGCTTTTC
Downstream sequence
TAACTTCTTATTTTCTTAAAAAGAGCTTACTTAAATGAATATGCTGCTTTGTAAGTTAATAGGGCATAAACCAAATTAAATCACCATGTCGGAAATTGTT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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