Basic Information
VIS ID
TVIS44011342
Fusion event
HTLV-1-chr4 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
q31.21
Reference genome
GRCh37/hg19
Start
142939430/142018277 (Hg38)
End
142939430/142018277 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-12113/Upstream/16510970; hsa-mir-1305/Downstream/1325183;
Nearest TSS
ENST00000502981/Upstream/296495; ENST00000514766/Downstream/287555;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/381107, chr4-CpG: 111/Downstream/827510
Nearby gene
INPP4B(-9752) ;
Nearest cancer related gene
INPP4B(TSG, -9752) ;
Upstream sequence
AAGCCTGGAGCCAGCAGGGGCTTTCTGAAAAATGGCATGGAGAGGGAAGCATAGCCAACCACCCCTCTCCCCAACAATGCTAAATATATAGCACATATAG
Downstream sequence
TATATAATATTGTACACATACAGTTcaatctagtgaaggagacagacaagaaaacacaactaaatgacaagttGGACCTAGGGTGGAGAGGGAGACAGAG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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