Basic Information
VIS ID
TVIS44011343
Fusion event
HTLV-1-FREM3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
q31.21
Reference genome
GRCh37/hg19
Start
144604607/143683454 (Hg38)
End
144604607/143683454 (Hg38)
Orient
-
Location type
Intronic
Target gene
FREM3
Nearest miRNA
hsa-mir-12113/Upstream/339919; hsa-mir-1305/Downstream/2725129;
Nearest TSS
ENST00000502981/Upstream/62402; ENST00000568324/Downstream/17221;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/123660, chr4-CpG: 123/Downstream/16215
Upstream sequence
cccaactatggaagtggtaaagggagaccctcctctcctaaacacacacccccattggagaagctgaaggtctgtttgcagaagtttccaactttacctg
Downstream sequence
cagctgagtcagtttggagagctgagcaaaattcaggggtagaagaagcagcagaaaggccctgggagctcgctggttcccctagcaggccattcctgcc
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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