Basic Information
VIS ID
TVIS44011354
Fusion event
HTLV-1-TENM3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
q34.3
Reference genome
GRCh37/hg19
Start
182686700/181765547 (Hg38)
End
182686700/181765547 (Hg38)
Orient
-
Location type
Intronic
Target gene
TENM3
miRNAs that regulate target gene
hsa-mir-10b-5p ; hsa-mir-10a-5p ; hsa-let-7b-5p ; hsa-mir-1238-3p ; hsa-mir-670-3p ; hsa-mir-3679-3p ; hsa-mir-6749-3p ; hsa-mir-6792-3p ; hsa-mir-4691-5p ; hsa-mir-2355-5p ; hsa-mir-3124-3p ; hsa-mir-4502 ; hsa-mir-138-2-3p ; hsa-mir-660-3p ; hsa-mir-5193 ; hsa-mir-338-3p ; hsa-mir-589-3p ; hsa-mir-2115-3p
Nearest miRNA
hsa-mir-12113/Upstream/7341683; hsa-mir-1305/Downstream/403746;
Nearest TSS
ENST00000502981/Upstream/500518; ENST00000512480/Downstream/64426;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/1706081, chr4-CpG: 20/Downstream/375578
Upstream sequence
GCAACAACCCGCTATGAATCTCTGATTTCACGACTGAAAAATAAAAAGGGAAAAGAACAACACAATATGTTGTTACATATAGAAAAACATAACATAAGAT
Downstream sequence
GACCTCACAAATGTTGATTCAAAAAGAAGCAAACTGTTGTCAATGACTTTGGGGAAAAAACAGCTACTTTCAAGTCAAATCATCATAATATACTGCTAAG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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