Basic Information
VIS ID
TVIS44011360
Fusion event
HTLV-1-chr5 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
p15.2
Reference genome
GRCh37/hg19
Start
11906188/11906076 (Hg38)
End
11906188/11906076 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-10397/Upstream/1427931; hsa-mir-103a-1/Downstream/2919853;
Nearest TSS
ENST00000502646/Upstream/2033; ENST00000505877/Downstream/668561;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/1485, chr5-CpG: 46/Downstream/888784
Nearby gene
CTNND2(-2033) ;
Nearest cancer related gene
CTNND2(OG, -2033) ;
Upstream sequence
GCCAGTTTGATATTAAAATATCCTGAGTCCTGTGAGGGAAGACATGCAAGACCATTTTTTTCATCACACGTTTAATTGTAATTTTTATCTTAGTTCTCAG
Downstream sequence
AAAGGCAGTTCAATTACACTGAGTACGTGGTACAAGACAAATTAGCAGCACCATATCCATTAGGCCACATTATATTTCAAGAGATGTTCTTAGTTCCCAC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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