Basic Information
VIS ID
TVIS44011370
Fusion event
HTLV-1-DAB2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
p13.1
Reference genome
GRCh37/hg19
Start
39421637/39421535 (Hg38)
End
39421637/39421535 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA5A
Target gene
DAB2
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-26b-5p ; hsa-mir-93-5p ; hsa-mir-647 ; hsa-mir-6864-5p ; hsa-mir-604 ; hsa-mir-190b ; hsa-mir-4764-5p ; hsa-mir-190a-5p ; hsa-mir-3179 ; hsa-mir-7515 ; hsa-mir-548o-3p ; hsa-mir-4272 ; hsa-mir-1323 ; hsa-mir-6757-5p ; hsa-mir-144-3p ; hsa-mir-129-5p ; hsa-mir-8061 ; hsa-mir-4760-5p ; hsa-mir-874-3p ; hsa-mir-3157-3p ; hsa-mir-376a-5p ; hsa-mir-146b-3p ; hsa-mir-6799-3p ; hsa-mir-3173-5p ; hsa-mir-7976 ; hsa-mir-4677-3p ; hsa-mir-4693-3p ; hsa-mir-106b-5p ; hsa-mir-93-3p
Nearest miRNA
hsa-mir-10397/Upstream/863974; hsa-mir-103a-1/Downstream/14529969;
Nearest TSS
ENST00000502646/Upstream/12698; ENST00000603514/Downstream/3333;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/346401, chr5-CpG: 39/Downstream/3255
Nearest cancer related gene
DAB2(TSG, No orient, 0)
Upstream sequence
gaagtacagagaggttatggaatgtgcccaaggccatgtaacctgcaaccctgtagctaagatttgaacccaggaaatggtacttcagaaggtagttctc
Downstream sequence
aactactatCCAATTGTGCCCTGTTGGAGGCAGCCAGTGTTGAATGTTAGCCCTCTGTGTCCGTACCAGTCATCATTTGTTCCCCTAACCAGGAATTTGC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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