Basic Information
VIS ID
TVIS44011375
Fusion event
HTLV-1-FGF10 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
p12
Reference genome
GRCh37/hg19
Start
44304061/44303959 (Hg38)
End
44304061/44303959 (Hg38)
Orient
-
Location type
Intronic
Target gene
FGF10
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-335-3p ; hsa-mir-1305 ; hsa-mir-607 ; hsa-mir-3671 ; hsa-mir-1283 ; hsa-mir-7705 ; hsa-mir-186-3p ; hsa-mir-4705 ; hsa-mir-4762-5p ; hsa-mir-7152-5p ; hsa-mir-511-5p ; hsa-mir-502-5p ; hsa-mir-6830-3p ; hsa-mir-7162-5p ; hsa-mir-516b-3p ; hsa-mir-516a-3p ; hsa-mir-2115-5p ; hsa-mir-6841-3p ; hsa-mir-5699-3p ; hsa-mir-4421 ; hsa-mir-6748-3p ; hsa-mir-6826-5p ; hsa-mir-216b-5p ; hsa-mir-3977 ; hsa-mir-1915-5p
Nearest miRNA
hsa-mir-10397/Upstream/5746398; hsa-mir-103a-1/Downstream/9647545;
Nearest TSS
ENST00000502646/Upstream/429592; ENST00000502457/Downstream/84773;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/700411, chr5-CpG: 69/Downstream/504986
Nearby gene
FGF10(-1036) ;
Nearest cancer related gene
FGF10(OG, No orient, 0)
Upstream sequence
TACAGAGGGTTTTTAGAGATGTGGACAGCCTCTTTACCGCCATGACATTTGGCAAGAAATCATGAGTAAATAATGAGGCTAGGCTATTTAAATGTATTTA
Downstream sequence
GCAATTAATTTTCCTTTTTTTAGTATATTCTTGGAGGCAAACTGATGTATTGAAAGAGAAGAATTTGGCCTTCTGGTCTATTTCTTGAGACAGGAAGCCT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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