Basic Information
VIS ID
TVIS44011388
Fusion event
HTLV-1-FAM172A integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
q15
Reference genome
GRCh37/hg19
Start
93402702/94066997 (Hg38)
End
93402702/94066997 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA5B
Target gene
FAM172A
miRNAs that regulate target gene
hsa-mir-421 ; hsa-mir-330-3p ; hsa-mir-218-5p ; hsa-mir-1827 ; hsa-mir-6511a-5p ; hsa-mir-1910-3p ; hsa-mir-6835-3p
Nearest miRNA
hsa-mir-10397/Upstream/446209; hsa-mir-103a-1/Downstream/2012141;
Nearest TSS
ENST00000502646/Upstream/185396; ENST00000508383/Downstream/7723;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/445363, chr5-CpG: 41/Downstream/44251
Nearest cancer related gene
FAM172A(TSG, No orient, 0)
Upstream sequence
ttcgggccaatattcctgacaaacataggtgtaaaattactcaataaaataacaataaaccagattcaacagcacatcaaaaaggtaacacatcattatc
Downstream sequence
aagtaggatttacctagaaatgcaaggatggttcaacatatgcaaatcaattagtgtgatacagcacatcaacagaatgaagaacaaaaaccatatgatc
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate