Basic Information
VIS ID
TVIS44011400
Fusion event
HTLV-1-UIMC1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
q35.2
Reference genome
GRCh37/hg19
Start
176444017/177017016 (Hg38)
End
176444017/177017016 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA5G
Target gene
UIMC1
Nearest miRNA
hsa-mir-10397/Upstream/387516; hsa-mir-1229/Downstream/2781262;
Nearest TSS
ENST00000502646/Upstream/10265; ENST00000510933/Downstream/5586;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/10109, chr5-CpG: 66/Downstream/5482
Nearby gene
ZNF346(+5664) ;
Nearest cancer related gene
UIMC1(TSG, No orient, 0)
Upstream sequence
ggaggctgaggcaggagaatcacttgaacccaggaggcagaggttgcagtgagctgagattgcgccattgcactccagcctgggtgacaagtgtgaacct
Downstream sequence
ctgtcAaaataatgaaatgaaatatgaaatgaaatgaaaaatgaaatgaaataaaGAAGCCTGAGAAGTGGACTAGGATTGCAGCAAAGATGTGCCCCTG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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