Basic Information
VIS ID
TVIS44011404
Fusion event
HTLV-1-CDYL integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
p25.1
Reference genome
GRCh37/hg19
Start
4942428/4942194 (Hg38)
End
4942428/4942194 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA6B
Target gene
CDYL
miRNAs that regulate target gene
hsa-mir-141-3p
Nearest miRNA
hsa-mir-4645/Upstream/2088087; hsa-mir-10398/Downstream/206039;
Nearest TSS
ENST00000381078/Upstream/13499; ENST00000606767/Downstream/61464;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/164878, chr6-CpG: 41/Downstream/61557
Upstream sequence
GACACTCTGATCATTAAACCCCAGTGTGATCTTTCTAAGAATGCCTCAGGCTCTCTCATTTAGAAAGACTTAGTGCAACTCATTCATTTGAATGAGTTAA
Downstream sequence
TTCTTGCTCAATGCAAAGATCCCACAAACCTTGGGGGCTAGGCTGAGGTCCAGCCGCTAAACTCTGCAATTCCTCACTCTCCTGTTCATACACACACAGA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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