Basic Information
VIS ID
TVIS44011409
Fusion event
HTLV-1-RIPOR2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
p22.3
Reference genome
GRCh37/hg19
Start
24918811/24918583 (Hg38)
End
24918811/24918583 (Hg38)
Orient
+
Location type
Intronic
Target gene
RIPOR2
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-374a-5p ; hsa-mir-4674 ; hsa-mir-4314 ; hsa-mir-6749-3p ; hsa-mir-1260b ; hsa-mir-1260a ; hsa-mir-4437 ; hsa-mir-6778-3p ; hsa-mir-378g ; hsa-mir-4486 ; hsa-mir-6860 ; hsa-mir-612 ; hsa-mir-5189-5p ; hsa-mir-3187-5p ; hsa-mir-1285-3p ; hsa-mir-532-3p ; hsa-mir-1224-3p ; hsa-mir-6877-3p ; hsa-mir-6819-3p
Nearest miRNA
hsa-mir-3691/Upstream/6346703; hsa-mir-10398/Downstream/2229043;
Nearest TSS
ENST00000381078/Upstream/7413; ENST00000428903/Downstream/13414;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/7225, chr6-CpG: 36/Downstream/221109
Upstream sequence
CCCACCTATGCAAAGATCTTCCCAAAGTTTAGTTCCTCCCTAATTCATAAAGTTGGGACCATTAACTTCAGGAGCTACTTTTAGGAGGAATTACAGGCCC
Downstream sequence
AGAAGCCCTATTGCTTAAAACTTTGTCACTGACTGTTAAACTTCAAAATCTTCATGGACATTATTTTGGAGCCTGATTTATATCTGGAACTGAGGTCTCA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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