Basic Information
VIS ID
TVIS44011414
Fusion event
HTLV-1-ANKS1A integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
p21.31
Reference genome
GRCh37/hg19
Start
34935594/34967817 (Hg38)
End
34935594/34967817 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA6H
Target gene
ANKS1A
miRNAs that regulate target gene
hsa-mir-92a-3p ; hsa-mir-487a-5p ; hsa-mir-509-3p ; hsa-mir-487b-5p ; hsa-mir-4781-3p ; hsa-mir-6740-5p ; hsa-mir-744-3p ; hsa-mir-1263 ; hsa-mir-150-3p ; hsa-mir-4777-3p ; hsa-mir-4684-3p ; hsa-mir-622 ; hsa-mir-4307 ; hsa-mir-513a-5p ; hsa-mir-6862-5p ; hsa-mir-4253 ; hsa-mir-3945 ; hsa-mir-6847-3p ; hsa-mir-5196-3p ; hsa-mir-6854-5p ; hsa-mir-1205 ; hsa-mir-125a-3p ; hsa-mir-3197 ; hsa-mir-34a-5p ; hsa-mir-34c-5p ; hsa-mir-3665 ; hsa-mir-4316 ; hsa-mir-449a ; hsa-mir-449b-5p ; hsa-mir-4710 ; hsa-mir-548au-3p ; hsa-mir-558 ; hsa-mir-6087 ; hsa-mir-657 ; hsa-mir-6717-5p ; hsa-mir-6765-5p
Nearest miRNA
hsa-mir-1236/Upstream/727081; hsa-mir-10398/Downstream/502691;
Nearest TSS
ENST00000381078/Upstream/78552; ENST00000470698/Downstream/90431;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/77930, chr6-CpG: 75/Downstream/173207
Upstream sequence
GGTTTGCTAAGCGGTGGCACTGAGAAACAGAGAAAAACAAACGTAAGTTCAGTTCATTCAGCATTTCTGTGTCTTTCTTTCATGTATAATTTAAACATCC
Downstream sequence
TTCCCCACCCTACCCACCAAAAAATCTTCAGCCAAGAGTTAAGTTTTACCTTTTCTTCTGCTTGTTCTTTTTCCCTCTGGAATGTTCCAGTGCTACATAA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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