Basic Information
VIS ID
TVIS44011415
Fusion event
HTLV-1-DNAH8 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
p21.2
Reference genome
GRCh37/hg19
Start
38843571/38875795 (Hg38)
End
38843571/38875795 (Hg38)
Orient
-
Location type
Exonic
Fragile sites / regions
FRA6H
Target gene
DNAH8
miRNAs that regulate target gene
hsa-mir-19b-1-5p ; hsa-mir-4420 ; hsa-mir-181b-3p ; hsa-mir-181b-2-3p ; hsa-mir-499b-3p ; hsa-mir-499a-3p ; hsa-mir-8485
Nearest miRNA
hsa-mir-1236/Upstream/1320373; hsa-mir-10398/Downstream/198519;
Nearest TSS
ENST00000381078/Upstream/11826; ENST00000373256/Downstream/55576;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/160306, chr6-CpG: 67/Downstream/172736
Upstream sequence
GGAGCCCTTCTGGAATTAGAAAGCAGAGAAAAGCTTGAAGCCTTCTTACGGCAGCATGAAAGCAAGTTGGACTTACCAGAAATACCTAAAGGCTCAAATC
Downstream sequence
AAACCATGTATGAGTTTTATGTTACTGATTATGGTAAGCCCACTGAACTATACCTTAAATGAAATGACTTTTTTCAAATGAGAAAATATAAGCTTTCATA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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